Research Article | DOI: https://doi.org/-

Translational Evolution of Post-COVID Multisystem Disorders: From Long COVID to Immune-Mediated Neuro-Interstitial Syndromes

  • Michael Anderson *

1.Department of Translational Medicine and Immunology, Northwestern Medical Center, Chicago, United States.

*Corresponding Author: Michael Anderson

Citation: M Anderson, Translational Evolution of Post-COVID Multisystem Disorders: From Long COVID to Immune-Mediated Neuro-Interstitial Syndromes, International Journal of Medical Sciences and Research, ACP Publishers,1(1).

Copyright : © 2026 Michael Anderson, this is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Received: 09 May 2026 | Accepted: 15 May 2026 | Published: 27 May 2026

Keywords: translational medicine, long covid, immune dysregulation, interstitial lung disease, neuroinflammation, post-viral syndromes

Dr. Translational Evolution of Post-COVID Multisystem Disorders: From Long COVID to Immune-Mediated Neuro-Interstitial Syndromes

Post-acute sequelae of SARS-CoV-2 infection [PASC], initially characterized as Long COVID during 2020–2022, have undergone significant conceptual transformation. Early descriptions focused primarily on fatigue, respiratory symptoms, and neurocognitive complaints. However, translational and clinical research from 2023–2026 reveals a broader multisystem disorder involving immune dysregulation, interstitial lung pathology, neuroinflammation, and microvascular injury. Emerging evidence suggests overlap with autoimmune and granulomatous diseases, highlighting a shift from symptom-based classification to mechanistic, phenotype-driven frameworks. This article synthesizes current translational insights into disease evolution, pathophysiology, and clinical stratification of post-COVID syndromes.

Keywords:
translational medicine, long covid, immune dysregulation, interstitial lung disease, neuroinflammation, post-viral syndromes

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