Review Article | DOI: https://doi.org/-

Innovations in Clinical Trials for Sepsis Management: Translational Advances and Emerging Therapeutic Strategies

  • Dr. Neha Kulkarni *

1. Department of Clinical Pharmacology and Translational Medicine, Institute of Medical Sciences, Pune

*Corresponding Author: Dr. Neha Kulkarni

Citation: Neha Kulkarni, Innovations in Clinical Trials for Sepsis Management: Translational Advances and Emerging Therapeutic Strategies. International Journal of Medical Sciences and Research, ACP Publishers, 2(1).

Copyright : © 2026 Neha Kulkarni, this is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited

Received: 06 May 2026 | Accepted: 18 May 2026 | Published: 28 May 2026

Keywords: : sepsis, clinical trials, immune dysregulation, precision medicine, biomarkers, critical care, translational research.

Dr. Innovations in Clinical Trials for Sepsis Management: Translational Advances and Emerging Therapeutic Strategies

Sepsis remains a leading cause of mortality worldwide, characterized by dysregulated host immune responses to infection and subsequent organ dysfunction. Despite advances in critical care, therapeutic outcomes remain suboptimal. Clinical trials over the past decade have shifted from generalized treatment approaches to targeted and personalized strategies. This review explores recent developments in sepsis-related clinical trials, highlighting novel immunomodulatory therapies, biomarker-guided interventions, adaptive trial designs, and translational insights. The integration of precision medicine, artificial intelligence, and real-time monitoring technologies is reshaping the future of sepsis management. However, challenges such as patient heterogeneity and trial design complexity continue to hinder progress.

Keywords:
: sepsis, clinical trials, immune dysregulation, precision medicine, biomarkers, critical care, translational research.

References

1. Rhodes A., Evans L. (2017). Surviving Sepsis Campaign: International guidelines for management of sepsis. Critical Care Medicine, 45(3):486–552.
📘 View at Publisher 🎓 View at Google Scholar
1. Singer M., Deutschman C. (2016). The third international consensus definitions for sepsis. JAMA, 315(8):801–810.
📘 View at Publisher 🎓 View at Google Scholar
1. Seymour C., Rosengart M. (2015). Septic shock: Advances in diagnosis and treatment. JAMA, 314(7):708–717.
📘 View at Publisher 🎓 View at Google Scholar
1. Prescott H., Angus D. (2018). Enhancing recovery from sepsis. JAMA, 319(1):62–75.
📘 View at Publisher 🎓 View at Google Scholar
1. Hotchkiss R., Moldawer L. (2014). Sepsis and septic shock. Nature Reviews Disease Primers, 2:16045.
📘 View at Publisher 🎓 View at Google Scholar
1. van der Poll T., Shankar-Hari M. (2021). Sepsis and septic shock. The Lancet, 397(10291): 2040–2055.
📘 View at Publisher 🎓 View at Google Scholar
1. Marshall J. (2020). Why have clinical trials in sepsis failed? Trends in Molecular Medicine, 26(5): 439–446.
📘 View at Publisher 🎓 View at Google Scholar
1. Hernandez G., Ospina-Tascon G. (2019). Personalized medicine in sepsis. Intensive Care Medicine, 45(4): 569–571.
📘 View at Publisher 🎓 View at Google Scholar
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